Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.
Based on previous large-scale in silico quest fryer screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro.In addition to their known anticoagulants activity this potential inhibition could have an additional therapeutic effect on patients with COVID-19 disease.In this study we examined the binding of the Apixab